You can set up a print job to produce negative images. An imagesetter produces images on film that may need to be produced as negatives depending on which printing device you are using. Consult your print service provider to determine whether you can produce images on film.
You can specify to print with the emulsion down. Printing with the emulsion down produces a backward image on desktop printers.
Do not choose negative film if you are printing to a desktop printer.
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